Micro and Nanotechnology Adoption by the Pharmaceutical Industry Essay Example for Free

Micro and Nanotechnology Adoption by the Pharmaceutical Industry Essay Micro and nanotechnology is starting to show promise in the pharmaceutical industry. The two key questions in this field are ‘what is nanotech’ and ‘aren’t all drugs nanotech – after all, they are in the nano size range’. These can be answered fairly simply; Nanotechnology is where the nano-size of a substance affects its activity – the size placing the substance at the interface between quantum and material effects. The classic example to demonstrate these effects is that of gold nanoparticles. Bulk gold is insoluble and metallic-yellow in colour. However, once the gold is formulated as a nanoparticle it is soluble and the size of the particle determines its colour – from bright blue to vivid red. Two key areas where nanotechnology is showing promise in the pharmaceuticals industry are tools for drug discovery, and secondly in formulation and delivery systems. In the development of tools to support drug discovery, nanotechnology is developing a trend to move away from high throughput to high content screening, where greater information on fewer compounds is achieved. As our knowledge about drug-target interactions increases, it is becoming apparent that high-volume/low-content screening can miss extremely interesting interactions and effects. For example, SPR biosensors can detect a ligand binding step and measure the binding constants. But it cannot measure surface stresses caused by binding, which are an important factor for example in antibiotic efficacy against MRSA and VRE. Here nanomechanical cantilevers have been shown to be effective in providing extremely elegant information that can explain the difference between various drugs that appear to have the same binding kinetics.[i] The move to high content screening has been slow due to the large investments in high throughput screening laboratories and so new systems need to be compatible. However, where systems are compatible with these techniques – for example using 96 well plate platforms, adoption is possible. As a result, improvements and adoption is currently iterative, rather than revolutionary, but it is happening. With regards to nanotechnology in formulation and delivery science, there are a number of early adopters of nanotechnology in the pharmaceutical industry. Table 1 shows a number of types of nanoparticle formulations that are already approved for marketing. The full list of approved ‘nano-enabled’ products is very small and those that have made it to the market are generally reformulations of existing generic drugs. We are still awaiting the second-generation nanodrug, where the nano-effect is integral to the product activity. Nanotechnology appears to be following the classic technology adoption curve as shown in Figure 1. This shows the bell-shaped adoption curve for any technology, overlaid by the technology acceptance line. Nanotechnology appears to have passed through the hype and trough and is now starting to be slowly adopted. It appears that the problem for nanotechnology in formulation is one of risk. Companies need to get their products to market quickly to allow as much market exclusivity time as possible not to recoup their investment, as this is a sunk cost, but to recoup the cost of developing future drugs, the cost of which is becoming ever more expensive. The Tufts Center for Drug Development estimated that the cost of bringing a single drug to market was in the order of $1.2 billion in 2008, compared to $802 million in 2000.[ii],[iii] Given these issues, companies won’t adopt new technology unless they know that the technology has a clear and fast route to approval. This is particularly poignant in drug formulation and other rate-limiting activities that occur post-patent filing. Once a patent is filed, the clock is ticking on the product’s life. If a product is going to be a $1billion a year blockbuster, lost revenues will be at least $2.7 million for every day a product is held from the market. This produces a catch 22 scenario; no-one will take the risk to demonstrate a new technology, especially if it is competing with existing and proven methods, so no-one will see a clear adoption path and use it. This is reminiscent of the fledgling biotech industry 15-20 years ago. Pharma was focussed on small molecules and didn’t want to risk bringing into their portfolio relatively unstable products, with complex manufacturing methods and which were without a clear regulatory pathway. Now however, many traditional large-pharma refer to themselves as biopharma companies and Amgen and Genentech (prior to the Roche purchase) are in the top twenty pharma by revenue. Early adopters, such as Abraxis and Elan, have started to clear a pathway to approval, but as yet no company has developed a true nanodrug – ie one which was conceived as a nano-enabled product from first principles as opposed to using nano-formulation on existing products. Nanotech has a lot to offer the pharmaceuticals industry and if it follows previous technology examples such as biotech, the successful early adopters will reap the rewards. It still has a number of hurdles to leap, such as a clear regulatory pathway and a demonstration of value above and beyond current technologies, before it can become mainstream. However, there are significant efforts by industry and governments to help it to jump the technology adoption gap quickly and ensure it can assist in developing the next generation of products that are needed to solve some of the significant unmet medical needs faced by patients and healthcare professionals. [i] Ndieyira, J. W. et al. Nanomechanical detection of antibiotic–mucopeptide binding in a model for superbug drug resistance. Nature Nanotech. 3, 691-696 (2008). [ii] Outlook 2008, Tufts Center for Drug Discovery (Available at http://csdd.tufts.edu/InfoServices/ OutlookReportsRequest.asp) [iii] Outlook 2000, Tufts Center for Drug Discovery (Available at http://csdd.tufts.edu/InfoServices/ OutlookReportsRequest.asp)

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The Inevitable War World war I was a war of tragic loss between the dead, the wounded, and the missing. The war was between the allied forces, (France, Britain, United States, Russia) and the central powers, (Ottoman empire, Austria-Hungary, and Germany). Many people when learning about World War I in class or in books don’t see or understand the conglomeration of events that attributed to the start of this war. There was the assassination of Archduke Franz Ferdinand, Increase in imperialism, nationalism, the arms race, and many more factors from years before 1914 that led to the break out of WWI. In many cases the world was growing and countries were becoming greedy and power hungry, There were no â€Å"main reasons for the war. Rather a number of jumbled events that led to the inevitability of World War I. In years leading to the start of World War I in 1914 there were many factors that contributed to the outbreak of â€Å"the great war† as the people of that time called it. There neither was nor still is a first, second, third reason war broke out, it was a long time coming of events that were happening in the world. The Alliances in WWI had been mapped out long before this war, due to previous wars. In his Article â€Å" The Origins of the First World War† William Mulligan clearly maps out the alliances of the central powers and the Alliance powers. The â€Å"block† of alliances as Mulligan puts it started to be put together in 1879. These countries would sign treaties with one another to strengthen their security of an area. A couple years prior to the WWI outbreak a few countries some allies some not worked together to calm down tensions in the Balkans. Though it was not as successful as it was thought out to be, though it did help keep th... ... and to have more resources than the â€Å"enemy†. In the 19th century the advancement of weaponry, technology and economic standing, proved to be too tense and when you add all the events leading up to 1914 together you get one big bubble that just has gotten too big for itself and is ready to burst at the seams with one more event or reason for countries to show whose bigger and better. The idea of peace is something everyone in the world likes to think is real, though in reality humanity is too arrogant and greedy to be able to settle their differences whether it be color of skin, whose got a bigger navy/gun. World War I was proof of this fact that war is inevitable. Even through diplomatic strategies and peace treaties there will always be someone whether it be a country in whole or one individual that will be there to tip the balance when the â€Å"bubble† get too big.

Does Music Really Create Better Students Education Essay

In 1981 Bob Marley died of malignant melanoma, a unsafe malignant neoplastic disease found in the toe. â€Å" He was a large musical figure to the universe: his music spoke to an exhausted and oppressed coevals that had experienced incredible poorness, racism, hungriness, and force † ( HistoryWorld 2 ) .A Bob Marley ‘s lazy, loosen uping reggae music connected non merely with his Jamaican chaps, but besides to the young person in the United States and Western Europe so efficaciously that he was looked upon as one of the most influential political figures in the western world.A Bob Marley, a hapless Jamaican Rastafarian of 30 old ages, was lifted to a place of unofficial but immensely important political power by nil more than his religious, socially cognizant music.A Bob Marley is one of many instrumentalists that have proved that music can hold a profound consequence on many facets of humanity. Music is the most common linguistic communication in the western world.A Books must be translated, addresss interpreted, symbols and hand-gestures explained.A Music, on the other manus, is different.A American, Chinese, Russian, Italian, and German instrumentalists all â€Å" read † and â€Å" hear † the same music, â€Å" enchantment † chords the same manner, and know the same musical â€Å" alphabet. â€Å" A The alone uniformity of music makes it the lone linguistic communication that can be understood at face value by, rather literally, everyone who hears it.A While music is heard, on the most basic degree, uniformly by every hearer, it is wholly unfastened to reading. A It is about certain that each and every hearer who hears the exact same composing, in the exact manner, at the exact same clip, will construe it in a wholly original way.A A A A A A A The uniformity of linguistic communication and originality of reading that music provides causes it to unite both the logical â€Å" left-brain † and the originative â€Å" right-brain † in ways which no other medium renders possible.A For illustration, Miles Davis ‘s legendary free wind album Bitches Brew was captured in one recording and is wholly improvisational with perfectly zero anterior planning.A The antonym, nevertheless, can be seen in the preciseness and technically pristine playing of the great classical fiddle ace, Itzhak Perlman.A Both Davis and Perlman are playing nil but the standard 12 notes found in the musical alphabet.A Both exhausted countless hours for the huge bulk of their lives practising their trade, honing their accomplishments, analyzing the elaboratenesss of music theory, and the natural philosophies of their peculiar instruments.A The consequences of all of this pain-staking research and pattern, when interpreted and utilized by two d ifferent heads, are entire opposites.A On the one manus, the consequence is musical flawlessness – on the other, its opposite.A Both are superb, both are rooted in a really scientific and precise survey of music, both are wholly originally and are really different from one another.A This unusual combination of logic and creativeness becomes increasing apparent when music is utilized in the acquisition procedure and makes music critical portion of a kid ‘s instruction due to its consequence on concluding abilities and possible as a larning tool in many scenes. â€Å" Music is a powerful tool and as seen can dramatically better and enrich everybody. It makes sense to force music instruction and to let immature coevalss to derive these fantastic benefits – higher intelligence through increased originative thought, job resolution and physically stronger encephalons, a higher perceptual experience of life including better attitudes, strong desires to accomplish and carry through and higher ego esteem, better developed subject, survey accomplishments, concentration, communicating and squad accomplishments which transfer from instruction through to career and a better apprehension of communities and society † ( Guth 1 ) . A Music holds tremendous potency for helping in the educational process.A At the root of music ‘s possible as an educational tool is the alone manner that affects the human brain.A In recent old ages, scientists have made amazing finds demoing that music has a significant consequence on a hearer ‘s concluding abilities.A Scientists have been analyzing the effects of music on persons ‘ concluding abilities since the Gallic scientist Dr. Albert Tomatis began analyzing the effects of music composed by Amadeus Mozart on autistic kids in the late 1950's.A Children were trained to prove out how music effects their public presentations. At the terminal of preparation, all the kids were able to execute simple tunes by Beethoven and Mozart. When they did â€Å" they were so subjected to spatial-temporal logical thinking trials calibrated for age, and their public presentation was more than 30 % better than that of kids of similar age given either computing machine lessons f or 6 months or no particular preparation. † ( Bridgett 3 ) Since so legion scientist at the helm of legion surveies have concluded non merely that music has a positive consequence on the encephalon ‘s capacity to believe critically, but that music can arouse drastic alterations in temper and heed. A survey published in May of 2001 by Atkinson College ‘s Psychology Department examined the cogency of the Mozart Effect.A The research workers tested the effects of listening to a bright, up-tempo piece of music on spacial logical thinking and compared them to the effects of listening to a slow, sad piece of music.A They measured non merely the participants ‘ ability to ground following hearing to the piece but besides the consequence that the piece had on their mood.A They found that those who listened to the sad music experienced feelings of ennui or unhappiness and performed significantly worse on the concluding trial. The survey concluded that music ‘s consequence on concluding and test-taking abilities is really a bypr oduct of the effects music has on mood.A They concluded that the Mozart Effect resulted in â€Å" an sweetening of spatial-temporal logical thinking public presentation after listening to Mozart ‘s music for 10 proceedingss depends on the person and the particular undertakings chosen. † ( Bridgett 6 ) Then In 2008 the Osaka School of Medicine conducted a survey that expanded on this concept.A The 2008 survey examined topics ‘ encephalons as they listened to music.A This survey focused on the key of the music and its consequence on the brain.A The survey found that music composed in a major manner ( which tends to sound â€Å" happier † ) reduces emphasis degrees and can greatly cut down mental weariness which can halter the encephalon ‘s ability to treat information and do decisions.A Music composed in a minor manner ( which tends to sound â€Å" sad † ) besides had a positive consequence on the encephalon but non to the same extent.A A While the music does impact the human encephalon unusually and positively, the possible benefits music can convey to pupils are non limited to its mensurable impact on the brain.A Music is besides an effectual tool for larning a assortment of accomplishments that are good to pupils ‘ mundane lives in the long term, including logical thinking and analytical abilities, teamwork, and discipline.A One accomplishment that music helps to learn that is really closely related to its antecedently mentioned effects on encephalon chemical science is by conditioning pupils to look at and analyze state of affairss creatively.A Music presents an remarkably synergistic and entertaining manner of learning pupils to believe critically and to work out jobs that are frequently abstract and subjective in nature.A â€Å" The substance of drama in really immature kids is normally comprised of the environmental objects and experiences to which they have been exposed. If the music environment is sufficiently rich, there will be a uninterrupted and of all time richer spiral of exposure to new musical elements followed by the kid ‘s playful experimentation with these elements. † ( Suda 6 ) Music instantly teaches pupils to do abstract associations between what their fingers do and what they hear come out of their instrument.A Students can instantly get down, merely by larning a simple tune that they hear on a regular footing ( Happy Birthday, Twinkle Twinkle Little Star, etc. ) , larning to organize and do these associations.A Once pupils learn to read music an wholly new kingdom of possibility is opened.A Students so get down doing associations between what they read on the piece of music, what note they are to play ( A, C # , D, Bb, etc. ) what their fingers should make to properly p lay the note ( on many instruments this may affect a determination between to feasible methods of playing the same note ) , and what the note will sound like in context.A When reading music, nevertheless, this melodious reading is accompanied by an every bit of import rhythmic reading.A A A A A A A Rhythm is highly of import to any piece of music and is an effectual tool for learning fractions and division.A Being able to split is critical to being able to read rhythms.A The basic rhythmic pulsation of a piece of music is called the beat.A You may detect a performing artist ‘s pes tapping as he plays.A Performers frequently tap their pes on each round or every other beat.A The velocity with which the beats pass is called the pacing. Throughout a work, the music will be notated with a series of specific types of notes.A Among these are whole notes, half notes, one-fourth notes, and 8th notes.A In 4/4 or â€Å" common clip, † if a note is marked with a whole note the note will be held for four beats.A If marked with a half note it will be held for half of four beats.A In order to decently read a beat a pupil must larn how to divide.A Harmonizing to a recent survey on a school, â€Å" 76 per centum of kids enrolled in the music plan performed above norm on their math ematical scrutinies † ( Edarticle.com 2 ) . This clearly makes rhythm an effectual tool for larning peculiar mathematical accomplishments. More of import than the specific accomplishments that reading music and rhythm aid to learn is the fact that public presentation of a piece of written music requires insistent and changeless exercise of these skills.A A While reading a piece of music a individual must travel through all the associations necessary to play a note that they see written and at the same time analyze the peculiar rhythmic marker and keep the note for the proper duration.A Before the note has been sounding for its full continuance, the performing artist or pupil must already be treating the following note and finding its proper rhythmic value.A A piece of music every bit simple as â€Å" Jingle Bells † will necessitate a pupil to do this association over one hundred times.A Scientists have discovered that larning to read music or play a musical instrument develops higher believing skills.A † The kid who is skilled at music excels at problem-solving, rating, and analysis.A Music reading uses the same part of the encephalon that ‘s used in mathematical thought † ( Schellenberg 4 ) .A That ‘s why so many adept instrumentalists are besides rather good in math.A Music requires changeless mental exercising that can fix the head with the ability to do split-second analyses in any state of affairs. A A A Not merely does music promote a pupil to work independently, it besides encourages pupils to join forces with others and work as portion of a team.A For most kids, athleticss squads are the lone chance to larn how to work as portion of a team.A Sports, nevertheless, are highly limited in their ability to provide different ability levels.A Sports tend to offer squads for really specific age degrees and, at each interval, there is a really limited scope of accomplishment levels.A This often consequences in the exclusion of kids who, due to their physical properties or skill degree, can non maintain gait with the rate at which other kids their age learn.A Sports, by nature, are besides highly competitive.A This competition consequences in competition non merely between squads, but between team-mates and consequences in the exclusion of kids who can non efficaciously assist their squad win.A â€Å" Music allows people of all ages and accomplishment degrees to take part and join fo rces † ( Guth 1 ) . Unlike athleticss, which is limited to athletic peoples, music is something that ensures people that no affair what their ability degree or when they began to larn about music, can bask the educational benefits that music offers.A A A A A A A A A A A A A A A A A A Music may besides be used to profit pupils in the survey of History.A It is important for a pupil to hold a thorough apprehension of the societal and cultural context of a historical event if he or she is to understand it completely.A For this ground CollegeBoard has stated that the surveies of â€Å" cultural, economic, political, and societal developments and artistic look and rational discourse are the main aims of their Advanced Placement European classs † ( Collegeboard.com 1 ) .A Music is a microcosm of the society that produces it, and is, hence, reveals much about the thoughts and doctrines of a clip period.A The late seventeenth century and the mid eighteenth century were know as the â€Å" Age of Enlightenment † a clip of progressive idea and philosophy.A This is apparent in the music of the time.A Around the bend of that century came the morning of the Classical Period.A This was a clip of complex, yet subdued music.A Composers like Wolf gang Mozart and Franz Shubert composed spectacularly complex and intellectually stimulating music that reflected the meditative, subdued philosophical nature of much of European society. In short, music is intended to be a vehicle for self-expression and in a universe where so much history is left off the functionary record, music is the lone penetration we have into the elaboratenesss of society that would otherwise be lost forever.A Exposure to the music of different civilizations and even different categories or societies within a peculiar civilization shows us how the universe looked through the eyes of those who were at that place and helps us to understand the societal context of the events that we study in history category. A A A A A A A A A A A Music is besides utile in the survey of English, much in the same manner that it ‘s utile in the survey of History.A Literature and music, over the class of history, both evolve as parts of larger artistic movements.A Romanticism, Impressionism, Realism, and other artistic motions all have distinguishable features that are seeable through the scrutiny of all artistic media.A For case, Romantic authors wrote about the extremes of human emotion.A Edgar Allen Poe wrote of horror and enigma and many other authors wrote of freedom, joy, hatred, fright, and the full spectrum of human emotion.A â€Å" Music of the Romantic period explored the same full scope through the usage of complex, modulating harmoniousness and wild swings in pacing and dynamic † ( HistoryWorld 8 ) A Through the observation of music of assorted clip periods and civilizations, much can be learned about the larger artistic motions of which plants of literature were a portion. Music ‘s possible educational benefits are countless, but doing these benefits accessible to kids can show rather a challenge.A There are, nevertheless, several ways that music can be made more readily available to students.A The first and most straightforward manner to advance music instruction is to do instruments more available to pupils outside of the classroom.A Music instruction is often available through private teachers but, due to fiscal or other restraints, is frequently non a feasible option.A In the past 50 old ages, direction in the humanistic disciplines have alternately ascended and descended in their popularity, verve, and support, particularly in the K-12 classs. â€Å" Music has taken some of the biggest and more frequent cuts among the humanistic disciplines due, in great portion, to the high costs of sheet music and instrument purchase and fix. Other humanistic disciplines direction such as ocular humanistic disciplines, dance, and choir have suffered great ly from clip to clip, but music seems to hold taken the greatest hit † ( Guth 2 ) . Many of these establishments, are sustained by authorities money or the contributions of private citizens.A This greatly limits the support that is available for new extracurricular activities or the enlargement of those that are in topographic point already. A A A A A A A A A A A A Integrating music into the current instruction system would let for the sweetening of the nucleus capable affair upon which simple, in-between, and high school instruction is based.A While music ‘s utilizations as a instruction aide do it highly utile, incorporating musical analysis into the nucleus course of study would let pupils to enrich their instructions and would besides expose them to a linguistic communication that is genuinely cosmopolitan and is proven to heighten their heads ability to analyse and reason.A The usage of music in the instruction in some signifier or another will expose pupils to a sophisticated cosmopolitan art-form that is both aesthetically and practically valuable.

Edisons Invention of the Phonograph